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听力受损会增加痴呆风险?我默默地摘下了耳机

中国助听器信息网   来源:未知   作者:admin
本期内容给大家推荐的一曲《悲惨世界》(Les Miserables)中的歌曲《I Dreamed a dream》(该歌曲是由才华横溢、帅气逼人的何深文老师分享)。大家可以伴随着轻松的音乐节奏,了解一下神经领域最近的研究进展。最后来一碗“鸡汤”,开心快乐地学习~
I Dreamed A Dream
Sarah Àlainn - SARAH
一、双语资讯
今日分享1个小研究~
1、听力减退增加痴呆风险
[1] Association of Hearing Loss With Dementia
➤ 听力减退增加痴呆风险
➤ 听力减退和痴呆的关系
[2] Importance: Hearing loss (HL) may be amodifiable risk factor for dementia, and longitudinal studies are needed toexamine the association of HL and dementia.
➤ 重要性:听力减退系痴呆的可控性,危险因素,因此对于听力丧失和痴呆的纵向研究很有意义。
➤ 重要性:听力减退可能是痴呆的可干预危险因素,有必要针对这一因素与痴呆的相关性开展纵向随访研究。
[3] Objective: To investigate the associationof HL with incident dementia in Taiwanese adults in the general population.
➤ 目的:探究中国台湾一般成年人群中听力减退与痴呆发病的关系。
[4] Design, Setting, and Participants : Thispopulation-based cohort study collected data from the National Health InsuranceResearch Database of Taiwan. Patients newly diagnosed with HL from January 1,2000, through December 31, 2011 (n=8135), constituted the exposed (HL) group.
➤ 研究方案、设置及被纳入者:本人群队列研究收集了2000年1月1日至2011年12月31日之间中国台湾健保数据库中所记录首次诊断为听力减退的患者(n=8135),作为研究的暴露组(HL组)。
[5] The HL group patients were matched by sex,age, residence, and insurance premium to individuals without HL (non-HL group)(n=8135). Data were analyzed from January 1, 2000, to December 31, 2013.
➤ 根据性别、年龄、居住地、保险级别,将HL组与非HL组(n=8135)进行匹配以保证组间可比性,数据分析自2000年1月1日开始,至2013年12月31日结束。
[6] Exposure: Hearing loss defined accordingto International Classification of Diseases, Ninth Revision, ClinicalModification (ICD-9-CM) codes.
➤ 暴露标准:听力减退依据国际疾病分类临床修订第9版 (ICD-9-CM) 进行定义。
[7] Main Outcomes and Measures: Dementia classified according to ICD-9-CM codes.
➤ 主要结果与指标:痴呆依据ICD-9-CM进行分级。
[8] Results: Of a total of 16 270 participants(9286 [57.1%] men; mean [SD] age, 65.2 [11.1] years), 1868 developed dementia.The dementia incidence rate in the HL group was higher than that in the non-HLgroup (19.38 [95% CI, 18.25-20.57] per 1000 person-years vs 13.98 [95% CI,13.01-15.00] per 1000 person-years) during the follow-up period.
➤ 结果:16270例研究对象(男性,9286例[57.1%];平均年龄[SD],65.2岁[11.1%])中,有1868例发展为痴呆。随访期间,HL组痴呆(19.38/1000人[95%CI,18.25-20.57]发生率高于非HL组(13.9/1000人[95CI,13.01-15.00])。
➤ 结果:在所有的16270名参与者中,9286名(57.1%)为男性,平均年龄65.2±11.1岁,有1868人发展为痴呆,在随访期间,HL组的痴呆发病率(19.38/千人·年,95%CI:18.25-20.75/千人·年)高于非HL组 (13.98/千人·年,95% CI:13.01-15.00/千人·年)。
[9] In the fully adjusted multivariate Coxproportional hazards regression model applied for risk analysis, patients withHL had a significant risk of dementia (hazard ratio [HR],1.17; 95% CI,1.07-1.29; false discovery rate [FDR] P=.003).Subgroup analysis revealed that, among 3 age groups (45-64, 65-74, and ≥75 years), the group aged 45 to 64 years was associated with a riskof dementia (HR,2.21[95% CI, 1.57-3.12]; FDR P<.001).
➤ 经充分校正的多因素Cox比例风险模型分析, HL组存在显著的痴呆风险,其风险比(HR)为1.17(95% CI:1.07-1.29),伪发现率(FDR)P值为0.003。但亚组分析显示,3个年龄组 (45-64岁, 65-74岁,≥75岁)中,只有45-64岁组与痴呆发生风险相关(HR2.21,95% CI:1.57-3.12; FDR P < .001)。
[10] In sensitivity analysis, the presence ofHL among those aged 45 to 64 years (HR,1.40; 95% CI,1.12-1.75; FDR P=.01) wasassociated with a risk of dementia.
 ➤ 敏感性分析同样显示45-64岁人群中存在听力减退者具有更高的痴呆风险(HR 1.40,95% CI:1.12-1.75,FDR P = .01)。
[11] Conclusions and Relevance: In this study,hearing loss was positively associated with a risk of dementia, especially inpatients aged 45 to 64 years. Hearing protection, screening, and treatment maybe used as strategies for mitigating this potential risk factor.
 ➤ 结论和意义:在这项研究中,听力损失与患痴呆症的风险呈正相关,特别是在45岁至64岁的患者中。听力保护、筛查和治疗可作为策略,以减轻这一潜在的危险因素。

听力受损会增加痴呆风险?我默默地摘下了耳机:/a/tl/ar/2019/0808/1582.html

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